The neurodegenerative disorder
Parkinson's disease is associated with a lack of neuromelanin in the brain
areas the substantia nigra and locus coeruleus. This is thought to arise from a
reduction in dopaminergic pigmented neurons which leads to reduced dopamine
synthesis in the brain.
Parkinson's symptoms may
include:
- Tremor.
Rhythmic shaking, called tremor, usually begins in a limb, often your hand
or fingers. ...
- Slowed
movement, known as bradykinesia. ...
- Rigid
muscles. ...
- Impaired
posture and balance. ...
- Loss of
automatic movements. ...
- Speech
changes. ...
- Writing
changes.
Globally, the prevalence of Parkinson
disease (PD) has doubled in the past 25 years with global estimates in 2019
showing over 8.5 million individuals living with PD. Disability and death due
to PD are increasi
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